Recombinase (cre) Activity
MGI collects and annotates expression and activity data for
recombinase-containing transgenes and knock-in alleles.
Find recombinase-carrying alleles
- Search for alleles assayed for specificity/activity in an anatomical structure.
- Search for alleles by promoter/driver activity.
Cre Portal Tutorial
- How do I...
- .. find existing recombinase-expressing transgenes and knock-ins that have a given promoter (driver)?
- .. find the promoter (driver) that I'm looking for if it is not on the selection list?
- .. find a recombinase-containing transgene or knock-in that is expressed in a specific tissue?
- .. get a full list of all transgenes and knock-ins that express recombinase?
- .. order mice with a desired recombinase construct?
Recombinase Allele Data Include
21 Apr 2015
- Recombinase-containing knock-in alleles
- Recombinase-containing transgenes
- Total recombinase transgenes and alleles
- Drivers in recombinase transgenes
- Drivers in recombinase knock-in alleles
- Tissues in recombinase specificity assays
Recombinase Project News
October 29, 2009
- Data about cre-containing transgenes and knock-ins and their tissue specific activity are being curated from the
scientific literature and integrated from projects underway at collaborating organizations. (See the Collaborators tab, below).
- We are part of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium.
- List of available
strains expressing cre
MGI-Mouse Recombinase (cre): About
|Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes can be knocked out in particular tissues and at particular developmental time points. Other non-cre recombinases (such as Flp, Dre, phiC31, etc.) and various inducible forms of recombinases have been and are being developed. We are curating data about all recombinase-containing transgenes and knock-ins developed in mice to provide a comprehensive resource delineating known activity patterns and allowing users to find relevant mouse resources for their studies.|
|Available data will continue to increase. To retrieve all recombinase-containing transgenes and knock-in alleles, use RETRIEVE ALL ALLELES, above. |
|The Recombinase Activity project is funded by NIH grants OD011190 and HD062499.|